Article

Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathies

2025-06-09

Abstract excerpt

Parkinson’s disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 ( LRRK2 ) are associated with endolysosomal dysfunction across cell types, and carriers of LRRK2 mutations variably present with phosphorylated tau and α-synuclein deposits in post-mortem analysis. LRRK2 mutations increase the phosphorylation of Rab substrates including Rab12. Rab12 is expressed in neuronal and non-neuronal cells wit...

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Literature Corpus work: 7cd2f9ba-05fa-5be7-86c0-28afbe97e39c
DOI: 10.1101/2025.06.06.658328

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