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Article

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.

eLife - 24 Oct 2023

Dhekne Herschel S, Tonelli Francesca, Yeshaw Wondwossen M, Chiang Claire Y, Limouse Charles, Jaimon Ebsy, Purlyte Elena, Alessi Dario R, Pfeffer Suzanne R

Abstract excerpt

Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we showed previously that these phosphoRabs play an important role in LRRK2 membrane recruitment and activation (Vides et al., 2022). To learn more about LRRK2 pathway regulation, we carried out an unbiased, CRISPR-based genome-wide screen to...

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Identifiers

PMID: 37874635
DOI: 10.7554/eLife.87098
PMCID: PMC10708890

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