Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.

Acta neuropathologica - 23 Oct 2025

Buck Silas A, Malankhanova Tuyana, Strader Samuel, Ma Eileen B, Yim Sarah, Pratt Harrison W, Ervin John, Lee Edward B, Wang Shih-Hsiu J, Cohen Todd J, West Andrew B, Sanders Laurie H

Abstract excerpt

Parkinson's disease (PD) pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with endolysosomal dysfunction across cell types, and carriers of LRRK2 mutations variably present with phosphorylated tau and α-synuclein deposits in post-mortem analysis. LRRK2 mutations increase the phosphorylation of Rab substrates including Rab12 and Rab10. Rab12 and Rab10 are expressed in neuronal and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lysosomes

Share to Neurons

Share to Parkinson Disease

Share to rab GTP-Binding Proteins

Share to tau Proteins

Share to Tauopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 41128923
DOI: 10.1007/s00401-025-02951-x
PMCID: PMC12549747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies.PMID 41128923Read ↗

Accumulation of LRRK2-associated phospho-Rab12 degenerative lysosomes in tauopathiesSemantic proximity Read ↗

Rab12 regulates LRRK2 activity by promoting its localization to lysosomesSemantic proximity Read ↗

The LRRK2 kinase substrates Rab8a and Rab10 contribute complementary but distinct disease-relevant phenotypes in human neuronsSemantic proximity Read ↗

The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons.Semantic proximity Read ↗

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson’s disease vulnerable dopamine axonsSemantic proximity Read ↗

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.Semantic proximity Read ↗

Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.Semantic proximity Read ↗

The emerging role of LRRK2 in tauopathies.Semantic proximity Read ↗

In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’s diseaseSemantic proximity Read ↗

Rab8a dysregulation in Parkinson's disease: A convergence of genetic and molecular pathologies.Semantic proximity Read ↗

In-depth mass-spectrometry reveals phospho-RAB12 as a blood biomarker of G2019S LRRK2-driven Parkinson’sSemantic proximity Read ↗

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.