Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase

Abstract excerpt

Activating mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we showed previously that phosphoRabs play an important role in LRRK2 membrane recruitment and activation (Vides et al., 2022). To learn more about LRRK2 pathway regulation, we carried out an unbiased, CRISPR-based genome-wide screen to identify...

Topics

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• Cellular transport and secretion
• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Mice
• Mutation
• Parkinson Disease
• Parkinson's Disease Mechanisms and Treatments
• Phosphorylation
• rab GTP-Binding Proteins

Identifiers and source

Literature Corpus work

2b90dcee-402f-54a2-af02-602359ba0e50

DOI

10.1101/2023.02.17.529028