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Article

RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.

Nature communications - 29 Sept 2024

Li Xingjian, Zhu Hanwen, Huang Bik Tzu, Li Xianting, Kim Heesoo, Tan Haiyan, Zhang Yuanxi, Choi Insup, Peng Junmin, Xu Pingyi, Sun Ji, Yue Zhenyu

Abstract excerpt

The leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of RAB GTPases, and their phosphorylation levels are elevated by Parkinson's disease (PD)-linked mutations of LRRK2. However, the precise function of the LRRK2-regulated RAB GTPase in the brain remains to be elucidated. Here, we identify RAB12 as a robust LRRK2 substrate in the mouse brain through phosphoproteomics profiling and solve the structure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39343966
DOI: 10.1038/s41467-024-52723-6
PMCID: PMC11439917

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Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylationSemantic proximity Read ↗

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LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockadeSemantic proximity Read ↗

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