Article

Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and Morphogenesis

2022-06-12

Abstract excerpt

Cholangiocyte organoids can be used to model liver biliary disease; however, both a defined matrix in which to emulate cholangiocyte self-assembly and the mechano-transduction pathways involved therein remain elusive. We designed a series of defined viscoelastic hyaluronan hydrogels in which to culture primary cholangiocytes and found that by mimicking the stress relaxation rate of liver tissue, we could induce ch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c6e70409-d5f2-56a5-af5d-9ed8fb3a5097
DOI: 10.1101/2022.06.09.495476

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and MorphogenesisDOI 10.1101/2022.06.09.495476Read

Mechano-modulatory synthetic niches for liver organoid derivationSemantic proximity Read

Mechanical signalling through collagen I regulates cholangiocyte specification and tubulogenesis during liver developmentSemantic proximity Read

Bioinspired Hydrogels for 3D Organoid CultureSemantic proximity Read

Soft, dynamic hydrogel confinement improves kidney organoid lumen morphology and reduces epithelial <i>–</i> mesenchymal transition in cultureSemantic proximity Read

N-cadherin Adhesive Interactions Mechanically Modulate Phenotype of Pancreatic Stellate Cells via YAP-dependent Mechanosensing.Semantic proximity Read

Photo-click Decellularized Matrix Hydrogels for Generating Pancreatic Ductal OrganoidsSemantic proximity Read

Integrated mesenchymal and extracellular cues drive bioengineered liver tissue formation and functionSemantic proximity Read

Substrate stiffness and viscoelasticity influence fibroblast senescenceSemantic proximity Read

Stress-adaptive biomaterials with tunable yielding architectures regulate organoid morphogenesisSemantic proximity Read

Engineered basement membrane mimetic hydrogels to study mammary epithelial morphogenesis and invasionSemantic proximity Read

Directing Cholangiocyte Morphogenesis in Natural Biomaterial ScaffoldsSemantic proximity Read

Matrix Stiffness Regulates Mechanotransduction and Vascular Network Formation of hiPSC-Derived Endothelial Progenitors Encapsulated in 3D HydrogelsSemantic proximity Read