Article

Mechanical signalling through collagen I regulates cholangiocyte specification and tubulogenesis during liver development

2025-01-22

Abstract excerpt

Cholangiocyte dysfunction accounts for a third of liver transplantations, access to which is limited by a shortage of healthy donor organs. A promising alternative is the therapeutic use of human induced pluripotent stem cell (hiPSC)-derived cholangiocytes. However, the use of hiPSCs is impeded by a lack of knowledge regarding intrahepatic cholangiocyte development, limiting the generation of fully functional cell...

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Identifiers and source

Literature Corpus work: 9356fa0d-2065-5bca-ad37-65e956e64285
DOI: 10.1101/2025.01.22.633528

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