Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

N-cadherin Adhesive Interactions Mechanically Modulate Phenotype of Pancreatic Stellate Cells via YAP-dependent Mechanosensing.

Small methods - 1 Mar 2026

Zhang Simei, Li Jianpeng, Wu Shuai, Song Yiqun, Wu Jiaoxing, Gao Zhenchao, Li Yizhen, Liu Dongmei, Zhou Cancan, Zhu Yaomin, Wang Zheng

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) exhibits a dense desmoplastic stroma primarily composed of cancer-associated fibroblasts (CAFs), which largely originate from pancreatic stellate cells (PSCs). Upon activation, PSCs promote extracellular matrix (ECM) remodeling and increase tissue stiffness, which in turn reinforces PSC activation via nuclear localization of Yes-associated protein (YAP), creating a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix

Share to Hydrogels

Share to Mechanotransduction, Cellular

Share to Oligopeptides

Share to Polyethylene Glycols

Share to YAP-Signaling Proteins

Source

Identifiers

PMID: 41778319
DOI: 10.1002/smtd.202501659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

N-cadherin Adhesive Interactions Mechanically Modulate Phenotype of Pancreatic Stellate Cells via YAP-dependent Mechanosensing.PMID 41778319Read ↗

A Self-Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer.Semantic proximity Read ↗

Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8.Semantic proximity Read ↗

Photo-click Decellularized Matrix Hydrogels for Generating Pancreatic Ductal OrganoidsSemantic proximity Read ↗

Engineered extracellular matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoidsSemantic proximity Read ↗

Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and MorphogenesisSemantic proximity Read ↗

Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoidsSemantic proximity Read ↗

Molecular Cues Guiding Matrix Stiffness in Liver FibrosisSemantic proximity Read ↗

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cellsSemantic proximity Read ↗

Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cellsSemantic proximity Read ↗

Bioengineering and biomechanical approaches for pancreatic cancerSemantic proximity Read ↗

ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells.Semantic proximity Read ↗

The combined influence of viscoelasticity and adhesive cues on fibroblast spreading and focal adhesion formationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.