Article

Soft, dynamic hydrogel confinement improves kidney organoid lumen morphology and reduces epithelial <i>–</i> mesenchymal transition in culture

2021-11-10

Abstract excerpt

Pluripotent stem cell–derived kidney organoids offer a promising solution to renal failure, yet current organoid protocols often lead to off-target cells and phenotypic alterations, preventing maturity. Here, we created various dynamic hydrogel architectures, conferring a controlled and biomimetic environment for organoid encapsulation. We investigated how hydrogel stiffness and stress relaxation affect renal phen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56bc28b8-0acb-5bf7-93a9-cb5141100710
DOI: 10.1101/2021.11.10.467741

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Soft, dynamic hydrogel confinement improves kidney organoid lumen morphology and reduces epithelial <i>–</i> mesenchymal transition in cultureDOI 10.1101/2021.11.10.467741Read

Mechanical signalling through collagen I regulates cholangiocyte specification and tubulogenesis during liver developmentSemantic proximity Read

Viscoelastic Notch Signaling Hydrogel Induces Liver Bile Duct Organoid Growth and MorphogenesisSemantic proximity Read

Bioinspired Hydrogels for 3D Organoid CultureSemantic proximity Read

Mechano-modulatory synthetic niches for liver organoid derivationSemantic proximity Read

Engineering kidney developmental trajectory using culture boundary conditionsSemantic proximity Read

Effect of biochemical and biomechanical factors on vascularization of kidney organoid-on-a-chipSemantic proximity Read

Inside the Matrix: A pancreas-derived hydrogel for the culture of hiPSC-derived pancreatic endocrine cellsSemantic proximity Read

Soft extracellular matrix drives an endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cellsSemantic proximity Read

Modulation of human iPSC-derived hepatocyte phenotype via extracellular matrix microarrays.Semantic proximity Read

Substrate Stiffness Modulates Renal Progenitor Cell Properties via a ROCK-Mediated Mechanotransduction Mechanism.Semantic proximity Read

Ultrastructural comparison of human kidney organoids and human fetal kidneys reveals features of hyperglycemic cultureSemantic proximity Read

Seminiferous tubule–inspired coaxial bioprinting–derived extracellular vesicles restore Leydig cell steroidogenesis by restraining Wnt4/β-catenin signalingSemantic proximity Read