Article

Substrate stiffness and viscoelasticity influence fibroblast senescence

2025-08-27

Abstract excerpt

<h4>Summary</h4> Senescent cell accumulation has been implicated in aging and fibrotic disease, which are both characterized by increased tissue stiffness. However, the direct connection between tissue mechanics and senescence induction remains disputed in the literature. Thus, this work investigates the influence of hydrogel stiffness and viscoelasticity in promoting fibroblast senescence both in combination wit...

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Literature Corpus work: 75b1f0c6-e716-5202-9eed-e42e5a612eb0
DOI: 10.1101/2025.08.22.671571

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