Article

Integrated mesenchymal and extracellular cues drive bioengineered liver tissue formation and function

2025-08-30

Abstract excerpt

Human liver tissue engineering holds promise for creating physiological in vitro models but faces challenges replicating liver complexity. In the present study, we created bioengineered liver tissues (BLTs) utilizing three different cell types; human intrahepatic cholangiocyte organoids (ICOs), hepatic stellate cells (HSCs), and mesenchymal stromal cells (MSCs). Co-culturing with HSCs and MSCs accelerated growth...

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Literature Corpus work: 0f726510-f578-5151-8f76-925d1a0ce28b
DOI: 10.1101/2025.08.28.672087

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