Article

Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds

2021-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Patients with Alagille syndrome carry monogenic mutations in the Notch signaling pathway and face complications such as jaundice and cholestasis. Given the presence of intrahepatic ductopenia in these patients, Notch2 receptor signaling has been implicated in driving normal biliary development and downstream branching morphogenesis. As a result, in vitro model systems of liver epithelium are ne...

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Literature Corpus work: b89105aa-3db8-5a59-bf7b-0c46a54f823a
DOI: 10.1101/2021.04.09.439196

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