Article

Photo-click Decellularized Matrix Hydrogels for Generating Pancreatic Ductal Organoids

2026-02-18

Abstract excerpt

Pancreatic ductal organoids (PDOs) generated from human induced pluripotent stem cells (iPSCs) can be used to model pancreatic diseases and to conduct drug screening/testing. However, current protocols for generating PDOs rely heavily on tumor-derived Matrigel, which has been shown to upregulate oncogenes. Furthermore, Matrigel has undefined composition and weak mechanical properties that hamper mechanistic studie...

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Literature Corpus work: cbff3a56-0cce-54a2-ba45-c8a623170548
DOI: 10.64898/2026.02.16.706185

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