Association of centenarian polygenic score with disability-free survival and its modification effects on aging outcomes

Abstract excerpt

<title>Abstract</title> <p>Centenarians exhibit remarkable longevity, and exploring the genetic components associated with this longevity is crucial for understanding the mechanisms underlying human aging. We investigated genetic factors in Japanese centenarians, healthy agers aged 85–89 years, and controls. A genome-wide association study (GWAS) identified longevity-associated variants in <italic>APOE</italic> a...

Topics

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• Aged, 80 and over
• Aging
• Apolipoproteins E
• Case-Control Studies
• Cohort Studies
• Cyclin-Dependent Kinase Inhibitor p15
• Genome-Wide Association Study
• Longevity

Identifiers and source

Literature Corpus work

c6c908db-0a9d-598b-9136-4054242cd824

DOI

10.21203/rs.3.rs-6869504/v1