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Article

Increased genetic protection against Alzheimer's disease in centenarians.

GeroScience - 1 Apr 2026

Bae Harold, Song Zeyuan, Ali Amanat, Sasaki Takashi, Tesi Niccolò, Lords Hannah, Leshchyk Anastasia, Abe Yukiko, Hirose Nobuyoshi, Arai Yasumichi, Barzilai Nir, Weiss Erica F, Hulsman Marc, van der Lee Sven, van Schoor Natasja M, Huisman Martijn, Pijnenburg Yolande, van der Flier Wiesje, Reinders Marcel, Holstege Henne, Milman Sofiya, Perls Thomas T, Andersen Stacy L, Sebastiani Paola

Abstract excerpt

We constructed a polygenic protective score specific to Alzheimer's disease (AD PPS) based on the current literature among the participants enrolled in five studies of healthy aging and extreme longevity in the USA, Europe, and Asia. This AD PPS did not include variants on apolipoprotein E (APOE) gene. Comparisons of AD PPS in different data sets of healthy agers and centenarians showed that centenarians have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40615639
DOI: 10.1007/s11357-025-01774-8
PMCID: PMC12972374

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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