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Article

Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring.

GeroScience - 1 Apr 2022

Gunn Sophia, Wainberg Michael, Song Zeyuan, Andersen Stacy, Boudreau Robert, Feitosa Mary F, Tan Qihua, Montasser May E, O'Connell Jeffrey R, Stitziel Nathan, Price Nathan, Perls Thomas, Schork Nicholas J, Sebastiani Paola

Abstract excerpt

A surprising and well-replicated result in genetic studies of human longevity is that centenarians appear to carry disease-associated variants in numbers similar to the general population. With the proliferation of large genome-wide association studies (GWAS) in recent years, investigators have turned to polygenic scores to leverage GWAS results into a measure of genetic risk that can better predict the risk of...

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Identifiers

PMID: 35119614
DOI: 10.1007/s11357-022-00518-2
PMCID: PMC9135909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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