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Article

Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum.

The journals of gerontology. Series A, Biological sciences and medical sciences - 30 Apr 2021

Tesi Niccolo', van der Lee Sven J, Hulsman Marc, Jansen Iris E, Stringa Najada, van Schoor Natasja M, Scheltens Philip, van der Flier Wiesje M, Huisman Martijn, Reinders Marcel J T, Holstege Henne

Abstract excerpt

Studying the genome of centenarians may give insights into the molecular mechanisms underlying extreme human longevity and the escape of age-related diseases. Here, we set out to construct polygenic risk scores (PRSs) for longevity and to investigate the functions of longevity-associated variants. Using a cohort of centenarians with maintained cognitive health (N = 343), a population-matched cohort of older...

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Identifiers

PMID: 33216869
DOI: 10.1093/gerona/glaa289
PMCID: PMC8087277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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