Article

Increased Genetic Protection Against Alzheimer’s Disease in Centenarians

2025-06-03

Abstract excerpt

<h4>ABSTRACT</h4> We constructed a polygenic protective score specific to Alzheimer’s disease (AD PPS) based on the current literature among the participants enrolled in five studies of healthy aging and extreme longevity in the US, Europe, and Asia. This AD PPS did not include variants on Apolipoprotein E (APOE) gene. Comparisons of AD PPS in different data sets of healthy agers and centenarians showed that cent...

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Literature Corpus work: 8e3662e2-d731-5687-875f-0efdc2392ca3
DOI: 10.1101/2025.06.02.657442

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