Genetic determinants of centenarian longevity, as quantified by the 'CentPGS' score, are associated with a lower risk of multiple age-related diseases and a longer healthspan.

Abstract excerpt

<title>Abstract</title> <p>Centenarians exhibit remarkable longevity, and exploring the genetic determinants of that longevity is crucial for understanding the mechanisms of human ageing. Although APOE4 is the most common implicated negative factor in longevity, other genetic factors and their associated phenotypes are not fully understood. We conducted a genome-wide association study (GWAS) of 964 Japanese cente...

Topics

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• Aged, 80 and over
• Aging
• Apolipoproteins E
• Case-Control Studies
• Cohort Studies
• Cyclin-Dependent Kinase Inhibitor p15
• Genome-Wide Association Study
• Longevity

Identifiers and source

Literature Corpus work

12ef908e-b284-5015-bac9-6fb3e18ebac5

DOI

10.21203/rs.3.rs-3916561/v1