Article
Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score.
International journal of molecular sciences - 19 Sept 2022
Torres Guillermo G, Dose Janina, Hasenbein Tim P, Nygaard Marianne, Krause-Kyora Ben, Mengel-From Jonas, Christensen Kaare, Andersen-Ranberg Karen, Kolbe Daniel, Lieb Wolfgang, Laudes Matthias, Görg Siegfried, Schreiber Stefan, Franke Andre, Caliebe Amke, Kuhlenbäumer Gregor, Nebel Almut
Abstract excerpt
Longevity is a complex phenotype influenced by both environmental and genetic factors. The genetic contribution is estimated at about 25%. Despite extensive research efforts, only a few longevity genes have been validated across populations. Long-lived individuals (LLI) reach extreme ages with a relative low prevalence of chronic disability and major age-related diseases (ARDs). We tested whether the protection...
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