Article

Non-coding mutations at enhancer clusters contribute to pancreatic ductal adenocarcinoma

2023-07-06

Abstract excerpt

<title>Abstract</title> <p> Non-coding mutations (NCMs) that perturb the function of <italic>cis</italic> -regulatory elements (CRE, enhancers) contribute to cancer. Due to the vast search space, mutation abundance and indirect activity of non-coding sequences, it is challenging to identify which somatic NCMs are contributing to tumour development and progression. Here, we focus our investigation on the somati...

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Literature Corpus work: 29120bc4-5f53-534d-af88-76a1c49a13a3
DOI: 10.21203/rs.3.rs-3120592/v1

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