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Article

Klf4-Tymp axis promotes inflammation-driven early tumorigenesis by enhancing kras mutation-induced acinar-to-ductal metaplasia through Pi3k/Akt and Mek/Erk pathways.

Journal of experimental & clinical cancer research : CR - 7 May 2026

Yuan Qihang, Chen Junhong, Luo Peng, Liu Kai, Guo Fangyue, Xu Yao, Tong Mengying, Xiang Hong, Shang Dong

Abstract excerpt

BACKGROUND: Acinar-to-ductal metaplasia (ADM) is a pivotal step in pancreatic tumorigenesis, reversible in normal contexts but progressing to PanIN and pancreatic cancer (PC) in the presence of Kras mutation and inflammation. Thus, delineating exocrine cell heterogeneity and identifying regulators of ADM are essential for understanding pancreatic tumorigenesis. METHODS: We collected single-cell RNA sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42092950
DOI: 10.1186/s13046-026-03712-8
PMCID: PMC13474847

Genes

ADM
PC
CD24
GPX1
HMGB2
KRAS
S100A4
S100A9
TFF3
TYMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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