Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GATA6 in pancreatic cancer initiation and progression

17 Jun 2024

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy characterized by insidious onset and lack of effective therapy. The molecular pathogenesis of PDA remains to be understood fully. Transcriptional factor GATA6 is an important transcriptional regulator in normal pancreas development, particularly in the initial specification and differentiation of the pancreas. Recent studies have linked pancreatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Neuroendocrine Tumor Research Advances
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39717718
DOI: 10.1016/j.gendis.2024.101353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GATA6 in pancreatic cancer initiation and progressionPMID 39717718Read ↗

The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.Semantic proximity Read ↗

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancerSemantic proximity Read ↗

Multiple roles and regulatory mechanisms of the transcription factor GATA6 in human cancersSemantic proximity Read ↗

The Relationship between the Expression of GATA4 and GATA6 with the Clinical Characteristics and Prognosis of Resectable Pancreatic AdenocarcinomaSemantic proximity Read ↗

GATA6 impairs pancreatic cancer cells stemness by modulating Wnt/β-catenin signalingSemantic proximity Read ↗

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancerSemantic proximity Read ↗

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1Semantic proximity Read ↗

GATA6 identifies an immune-enriched phenotype linked to favorable outcomes in patients with pancreatic cancer undergoing upfront surgery.Semantic proximity Read ↗

Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult miceSemantic proximity Read ↗

A GATA6-centred gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.