Article

Non-coding mutations at enhancer clusters contribute to pancreatic ductal adenocarcinoma

2023-06-29

Abstract excerpt

Non-coding mutations (NCMs) that perturb the function of cis -regulatory elements (CRE, enhancers) contribute to cancer. Due to the vast search space, mutation abundance and indirect activity of non-coding sequences, it is challenging to identify which somatic NCMs are contributing to tumour development and progression. Here, we focus our investigation on the somatic NCMs that are enriched at enhancers from 659 p...

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Literature Corpus work: 365563aa-5f30-5ff2-9173-5445e170ee17
DOI: 10.1101/2023.06.28.546873

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