Article

Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces hyperarousal and enhanced cognition but impaired inhibitory control

2023-06-01

Abstract excerpt

<title>Abstract</title> <p>Hypocretin/Orexin (HCRT/OX) and dopamine (DA) are two key effectors of salience processing, reward and stress-associated behavior and motivational states, yet their respective roles and interactions are poorly delineated. We inactivated HCRT-to-DA connectivity by genetic disruption of Hypocretin receptor type-1 (Hcrtr1), Hypocretin receptor type-2 (Hcrtr2), or both receptors (Hcrtr1&2)...

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Literature Corpus work: c649d51e-cba8-5ff9-88b7-1d64a4201bfb
DOI: 10.21203/rs.3.rs-2938625/v1

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