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Article

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons.

Nature - 24 Jan 2013

Chaudhury Dipesh, Walsh Jessica J, Friedman Allyson K, Juarez Barbara, Ku Stacy M, Koo Ja Wook, Ferguson Deveroux, Tsai Hsing-Chen, Pomeranz Lisa, Christoffel Daniel J, Nectow Alexander R, Ekstrand Mats, Domingos Ana, Mazei-Robison Michelle S, Mouzon Ezekiell, Lobo Mary Kay, Neve Rachael L, Friedman Jeffrey M, Russo Scott J, Deisseroth Karl, Nestler Eric J, Han Ming-Hu

Abstract excerpt

Ventral tegmental area (VTA) dopamine neurons in the brain's reward circuit have a crucial role in mediating stress responses, including determining susceptibility versus resilience to social-stress-induced behavioural abnormalities. VTA dopamine neurons show two in vivo patterns of firing: low frequency tonic firing and high frequency phasic firing. Phasic firing of the neurons, which is well known to encode...

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Identifiers

PMID: 23235832
DOI: 10.1038/nature11713
PMCID: PMC3554860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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