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Article

Behavioral and sleep/wake characteristics of mice lacking norepinephrine and hypocretin.

Genes, brain, and behavior - 1 Aug 2006

Hunsley M S, Curtis W R, Palmiter R D

Abstract excerpt

We investigated the interaction between norepinephrine (NE) and orexin/hypocretin (Hcrt) in the control of sleep behavior and narcoleptic symptoms by creating mice that were deficient in both neurotransmitters. Mice with a targeted disruption of the dopamine beta-hydroxylase (Dbh) gene (deficient in NE and epinephrine) or the Hcrt gene were bred to generate double knockouts (DKOs), each single KO (Dbh-KO and...

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Identifiers

PMID: 16923149
DOI: 10.1111/j.1601-183X.2005.00179.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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