Behavioral and sleep/wake characteristics of mice lacking norepinephrine and hypocretin.

doi:10.1111/j.1601-183X.2005.00179.x

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Article

Behavioral and sleep/wake characteristics of mice lacking norepinephrine and hypocretin.

Genes, brain, and behavior - 1 Aug 2006

Hunsley M S, Curtis W R, Palmiter R D

Abstract excerpt

We investigated the interaction between norepinephrine (NE) and orexin/hypocretin (Hcrt) in the control of sleep behavior and narcoleptic symptoms by creating mice that were deficient in both neurotransmitters. Mice with a targeted disruption of the dopamine beta-hydroxylase (Dbh) gene (deficient in NE and epinephrine) or the Hcrt gene were bred to generate double knockouts (DKOs), each single KO (Dbh-KO and...

Topics

Amphetamine
Animals
Behavior, Animal
Brain
Dopamine Agonists
Electroencephalography
Electromyography
Epinephrine
Female
Genetic Predisposition to Disease
Intracellular Signaling Peptides and Proteins
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Neuropeptides
Orexins
Reaction Time

Source

Open in PubMed

Identifiers

PMID: 16923149
DOI: 10.1111/j.1601-183X.2005.00179.x

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