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Article

Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy.

Nature communications - 27 Nov 2020

Seifinejad Ali, Li Sha, Possovre Marie-Laure, Vassalli Anne, Tafti Mehdi

Abstract excerpt

Loss of muscle tone triggered by emotions is called cataplexy and is the pathognomonic symptom of narcolepsy, which is caused by hypocretin deficiency. Cataplexy is classically considered to be an abnormal manifestation of REM sleep and is treated by selective serotonin (5HT) reuptake inhibitors. Here we show that deleting the 5HT transporter in hypocretin knockout mice suppressed cataplexy while dramatically...

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Identifiers

PMID: 33247179
DOI: 10.1038/s41467-020-19862-y
PMCID: PMC7699625

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