Article

Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse Model

2026-05-21

Abstract excerpt

Stress is a commonly reported seizure precipitant and may contribute to the development of psychiatric comorbidities in epilepsy, yet how chronic stress interacts with epileptic circuits remains poorly understood. We investigated the impact of chronic restraint stress on physiological, behavioral, and synaptic outcomes in a mouse model of Dravet syndrome, specifically corticotropin-releasing factor (CRF) neurons i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ebc1fde0-2d53-586a-b185-2632b684d078
DOI: 10.64898/2026.05.19.723288

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse ModelDOI 10.64898/2026.05.19.723288Read

Enhanced synaptic transmission in the extended amygdala and altered excitability in an extended amygdala to brainstem circuit in a Dravet syndrome mouse modelSemantic proximity Read

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors.Semantic proximity Read

Chronic variable mild stress alters the transcriptome and signaling properties of the anterodorsal bed nuceleus of the stria terminalis in a sex-dependent mannerSemantic proximity Read

Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle poolsSemantic proximity Read

Chronic unpredictable stress promotes cell-specific plasticity in prefrontal cortex D1 and D2 pyramidal neuronsSemantic proximity Read

Scn8a voltage-gated sodium channel mutation alters seizure and anxiety responses to acute stress.Semantic proximity Read

Hypothalamic-pituitary-adrenal axis dysfunction worsens epilepsy outcomes and increases SUDEP riskSemantic proximity Read

Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice.Semantic proximity Read

The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice.Semantic proximity Read

The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behaviorSemantic proximity Read

Stress and Epilepsy: Multiple Models, Multiple OutcomesSemantic proximity Read

Spatiotemporal remodeling in the habenula marks the onset of depressionSemantic proximity Read