Back to search

Article

Chronic unpredictable stress promotes cell-specific plasticity in prefrontal cortex D1 and D2 pyramidal neurons

2019-03-05

Abstract excerpt

Exposure to unpredictable environmental stress is widely recognized as a major determinant for risk and severity in neuropsychiatric disorders such as major depressive disorder, anxiety, schizophrenia, and PTSD. The ability of ostensibly unrelated disorders to give rise to seemingly similar psychiatric phenotypes highlights a need to identify circuit-level concepts that could unify diverse factors under a common p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f015382b-85f0-5990-b010-da1b5bd829f4
DOI
10.1101/565499
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Chronic unpredictable stress promotes cell-specific plasticity in prefrontal cortex D1 and D2 pyramidal neuronsDOI 10.1101/565499
Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice.Semantic proximity
Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABA-ergic Parvalbumin Interneurons Attenuates Chronic Stress Adaptions in Male MiceSemantic proximity
Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibilitySemantic proximity
Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors.Semantic proximity
Individual differences in the chronic stress-induced depression-like behavior are mediated by the expression of Kcnj2 gene in the lateral septumSemantic proximity
Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signalingSemantic proximity
Chronic stress induces co-ordinated cortical microcircuit cell type transcriptomic changes consistent with altered information processingSemantic proximity
Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse ModelSemantic proximity
PV interneuron alterations in stress-related mood disorders: a systematic reviewSemantic proximity
Sex and Circadian Rhythm Dependent Behavioral Effects of Chronic Stress in Mice and Modulation of Clock Genes in the Prefrontal CortexSemantic proximity
Changes at glutamate tripartite synapses in the prefrontal cortex of a new animal model of resilience/vulnerability to acute stressSemantic proximity
Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks <i>in vivo</i>Semantic proximity
Select a neighboring publication to make it the new centre.