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Article

Hypocretin (orexin) is critical in sustaining theta/gamma-rich waking behaviors that drive sleep need.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2017

Vassalli Anne, Franken Paul

Abstract excerpt

Hcrt gene inactivation in mice leads to behavioral state instability, abnormal transitions to paradoxical sleep, and cataplexy, hallmarks of narcolepsy. Sleep homeostasis is, however, considered unimpaired in patients and narcoleptic mice. We find that whereas Hcrtko/ko mice respond to 6-h sleep deprivation (SD) with a slow-wave sleep (SWS) EEG δ (1.0 to 4.0 Hz) power rebound like WT littermates, spontaneous...

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Identifiers

PMID: 28630298
DOI: 10.1073/pnas.1700983114
PMCID: PMC5502606

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