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Article

Neuronal expression of a thyroid hormone receptor α mutation alters mouse behaviour.

Behavioural brain research - 15 Mar 2017

Richard S, Aguilera N, Thévenet M, Dkhissi-Benyahya O, Flamant F

Abstract excerpt

In humans, alterations in thyroid hormone signalling are associated with mood and anxiety disorders, but the neural mechanisms underlying such association are poorly understood. The present study investigates the involvement of neuronal thyroid hormone receptor α (TRα) in anxiety, using mouse genetics and Cre/loxP technology to specifically alter TRα signalling in neurons. We evaluated the behaviour of mice...

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Source

Identifiers

PMID: 28011173
DOI: 10.1016/j.bbr.2016.12.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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