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Article

A tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesis

2025-12-29

Abstract excerpt

Type I interferon (IFN) signaling is a central antiviral defense, with STAT2 driving the expression of IFN-stimulated genes (ISGs) to restrict viral infection. Many flaviviruses, including Zika virus (ZIKV), evade this pathway through non-structural protein 5 (NS5)-mediated ubiquitination and proteasomal degradation of STAT2, yet the contribution of this immune evasion strategy to viral fitness and pathogenesis re...

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Identifiers and source

Literature Corpus work
c6418125-8b3e-55e3-ba0a-4aaf753e6df2
DOI
10.64898/2025.12.28.696729
Open publication

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A tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesisDOI 10.64898/2025.12.28.696729
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