Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NS5 Conservative Site Is Required for Zika Virus to Restrict the RIG-I Signaling

14 Feb 2020

Abstract excerpt

During host-virus co-evolution, cells develop innate immune systems to inhibit virus invasion, while viruses employ strategies to suppress immune responses and maintain infection. Here, we reveal that Zika virus (ZIKV), a re-emerging arbovirus causing public concerns and devastating complications, restricts host immune responses through a distinct mechanism. ZIKV nonstructural protein 5 (NS5) interacts with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32117232
DOI: 10.3389/fimmu.2020.00051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NS5 Conservative Site Is Required for Zika Virus to Restrict the RIG-I SignalingPMID 32117232Read ↗

Zika Virus Proteins NS2A and NS4A Are Major Antagonists that Reduce IFN-�� Promoter Activity Induced by the MDA5/RIG-I Signaling PathwaySemantic proximity Read ↗

Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate ImmunitySemantic proximity Read ↗

Flavivirus Capsid Proteins Inhibit the Interferon ResponseSemantic proximity Read ↗

The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon SignalingSemantic proximity Read ↗

RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell DeathSemantic proximity Read ↗

A tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesisSemantic proximity Read ↗

Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2Semantic proximity Read ↗

Zika Virus-Encoded NS2A and NS4A Strongly Downregulate NF-κB Promoter ActivitySemantic proximity Read ↗

TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradationSemantic proximity Read ↗

TRIM22 suppresses zika virus replication by targeting NS1 and NS3 for proteasomal degradationSemantic proximity Read ↗

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral StrategySemantic proximity Read ↗

Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS SignalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.