Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition

10 Jan 2024

Abstract excerpt

Flaviviruses, including Zika virus (ZIKV) and Dengue virus (DENV), rely on their non-structural protein 5 (NS5) for both replication of viral genome and suppression of host IFN signaling. DENV and ZIKV NS5s were shown to facilitate proteosome-mediated protein degradation of human STAT2 (hSTAT2). However, how flavivirus NS5s have evolved for species-specific IFN-suppression remains unclear. Here we report...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to Mosquito-borne diseases and control
Share to Studies on Chitinases and Chitosanases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38195857
DOI: 10.1038/s42003-024-05768-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibitionPMID 38195857Read ↗

The Human STAT2 Coiled-Coil Domain Contains a Degron for Zika Virus Interferon EvasionSemantic proximity Read ↗

A tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesisSemantic proximity Read ↗

Host-Specific NS5 Ubiquitination Determines Yellow Fever Virus TropismSemantic proximity Read ↗

Structural basis for STAT2 suppression by flavivirus NS5Semantic proximity Read ↗

Dengue Virus Non-Structural Protein 5 as a Versatile, Multi-Functional Effector in Host–Pathogen InteractionsSemantic proximity Read ↗

Coevolutionary constraints of Zika virus nonstructural protein 5 replication and interferon antagonism activitiesSemantic proximity Read ↗

The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon SignalingSemantic proximity Read ↗

Suppression of Type I Interferon Signaling by Flavivirus NS5Semantic proximity Read ↗

Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2Semantic proximity Read ↗

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal DegradationSemantic proximity Read ↗

ISG15/USP18/STAT2 is a molecular hub regulating autocrine IFN I-mediated control of Dengue and Zika virus replicationSemantic proximity Read ↗

Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.