Article

The Human STAT2 Coiled-Coil Domain Contains a Degron for Zika Virus Interferon Evasion

2021-10-01

Abstract excerpt

The ability of viruses to evade the host antiviral immune system determines their level of replication fitness, species specificity, and pathogenic potential. Flaviviruses rely on the subversion of innate immune barriers including the type I and type III IFN antiviral systems. Zika virus infection induces the degradation of STAT2, an essential component of the IFN stimulated gene transcription factor, ISGF3. The m...

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Literature Corpus work: ea5d734d-12c7-5cc4-ad6d-0add3918ea77
DOI: 10.1101/2021.10.01.462781

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