Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2

2 Aug 2021

Abstract excerpt

The Interferon (IFN) response is crucial to restrain pathogenic infections. Investigations into flavivirus-host interactions reported that the high virulence is linked to innate immune evasion. Zika Virus (ZIKV) has developed diversified strategies to evade the innate immune system. We report that the viral protein NS2A counteracts the IFN response by strongly suppressing the IFN signaling. NS2A targets...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Malaria Research and Control
Share to Mosquito-borne diseases and control
Share to Viral Infections and Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34338586
DOI: 10.1080/21505594.2021.1935613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2PMID 34338586Read ↗

The Human STAT2 Coiled-Coil Domain Contains a Degron for Zika Virus Interferon EvasionSemantic proximity Read ↗

The Molecular Basis of Viral Inhibition of IRF- and STAT-Dependent Immune ResponsesSemantic proximity Read ↗

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon SignalingSemantic proximity Read ↗

Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathwaySemantic proximity Read ↗

INMI1 Zika Virus NS4B Antagonizes the Interferon Signaling by Suppressing STAT1 PhosphorylationSemantic proximity Read ↗

Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitroSemantic proximity Read ↗

Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2Semantic proximity Read ↗

Flavivirus Capsid Proteins Inhibit the Interferon ResponseSemantic proximity Read ↗

Zika Virus Proteins NS2A and NS4A Are Major Antagonists that Reduce IFN-�� Promoter Activity Induced by the MDA5/RIG-I Signaling PathwaySemantic proximity Read ↗

A tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesisSemantic proximity Read ↗

Suppression of Type I Interferon Signaling by Flavivirus NS5Semantic proximity Read ↗

The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon SignalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.