Article
An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction.
Nature communications - 29 Jan 2018
Xia Hongjie, Luo Huanle, Shan Chao, Muruato Antonio E, Nunes Bruno T D, Medeiros Daniele B A, Zou Jing, Xie Xuping, Giraldo Maria Isabel, Vasconcelos Pedro F C, Weaver Scott C, Wang Tian, Rajsbaum Ricardo, Shi Pei-Yong
Abstract excerpt
Virus-host interactions determine an infection outcome. The Asian lineage of Zika virus (ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after 2012 that enhances mosquito infection. Here we report that the same mutation confers NS1 to inhibit interferon-β induction. This mutation enables NS1 binding to TBK1 and reduces TBK1 phosphorylation. Engineering the mutation into a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.