Coevolutionary constraints of Zika virus nonstructural protein 5 replication and interferon antagonism activities

Abstract excerpt

The flavivirus nonstructural protein 5 performs multiple functions during infection, including RNA replication and type I interferon signaling antagonism. Although flavivirus NS5 proteins inhibit IFN signaling through distinct mechanisms, which suggests evolutionary flexibility, the evolutionary constraints for these activities to coexist within a single protein remain to be determined. Here, we mapped the Zika vi...

Topics

Open a Topic to create a Post that cites this publication.

• Evolution, Molecular
• HIV Research and Treatment
• Immune Evasion
• interferon and immune responses
• Malaria Research and Control
• Mosquito-borne diseases and control
• Viral Infections and Vectors
• Viral Nonstructural Proteins

Identifiers and source

Literature Corpus work

5a7475ab-ff99-507d-928a-a47e1cbc494b

DOI

10.64898/2025.12.23.696258