ISG15/USP18/STAT2 is a molecular hub regulating autocrine IFN I-mediated control of Dengue and Zika virus replication

Abstract excerpt

<h4>SUMMARY</h4> The establishment of a virus infection is the result of the pathogen’s ability to replicate in a hostile environment generated by the host’s immune system. Here, we found that ISG15 restricts Dengue and Zika viruses’ replication through the stabilisation of its binding partner USP18. ISG15 expression was necessary to control DV replication driven by both autocrine and paracrine type one interfero...

Topics

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• Cytokine Signaling Pathways and Interactions
• DEAD Box Protein 58
• DEAD-box RNA Helicases
• interferon and immune responses
• Mosquito-borne diseases and control
• RNA regulation and disease
• T-cell and B-cell Immunology
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

c4454024-b102-5f9a-b1f7-ff5c8eda313c

DOI

10.1101/784678