Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD

4 Feb 2025

Abstract excerpt

BACKGROUND: Cellular senescence, a hallmark of aging, has been implicated in Alzheimer's disease (AD) pathogenesis. Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are not fully understood. ATP-binding cassette transporter A1 (ABCA1) plays an important role in cholesterol homeostasis, and its expression and trafficking are altered in APOE4 and AD models. However,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholesterol and Lipid Metabolism
Share to Peroxisome Proliferator-Activated Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39901180
DOI: 10.1186/s13024-025-00802-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and ADPMID 39901180Read ↗

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and ADSemantic proximity Read ↗

Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer’s DiseaseSemantic proximity Read ↗

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's DiseaseSemantic proximity Read ↗

A Review of APOE Genotype-Dependent Autophagic Flux Regulation in Alzheimer's Disease.Semantic proximity Read ↗

APOE2, E3 and E4 differentially modulate cellular homeostasis, cholesterol metabolism and inflammatory response in isogenic iPSC-derived astrocytesSemantic proximity Read ↗

APOE3 Christchurch is associated with sphingolipids recycling and glial lipid remodeling in autosomal dominant Alzheimer’s diseaseSemantic proximity Read ↗

The Contributions of the Endolysosomal Compartment and Autophagy to APOEɛ4 Allele-Mediated Increase in Alzheimer's Disease Risk.Semantic proximity Read ↗

ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease.Semantic proximity Read ↗

Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological EffectsSemantic proximity Read ↗

<i>APOE</i> deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoidsSemantic proximity Read ↗

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.Semantic proximity Read ↗

ABCA7 and Pathogenic Pathways of Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.