Back to search

Article

TREM2-dependent senescent microglia conserved in aging and Alzheimer’s disease

2023-03-21

Abstract excerpt

Dementia in general, and Alzheimer’s disease (AD) in particular, are age-related diseases 1,2 . AD is associated with multiple causative factors 3,4 , among which local brain inflammation plays a significant role 5 . Microglia, the brain-resident immune cells 6,7 , are activated along the disease course 7 . Yet, their contribution to the disease progression is still controversial. Here, using high-throughput...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
880dbfe1-074a-5bc4-a9fc-b0d4af321ede
DOI
10.1101/2023.03.20.533401
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
TREM2-dependent senescent microglia conserved in aging and Alzheimer’s diseaseDOI 10.1101/2023.03.20.533401
Senescent Microglia Represent a Subset of Disease-Associated Microglia in P301S Mice.Semantic proximity
Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's DiseaseSemantic proximity
Aging Microglia—Phenotypes, Functions and Implications for Age-Related Neurodegenerative DiseasesSemantic proximity
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.Semantic proximity
Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer’s DiseaseSemantic proximity
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.Semantic proximity
Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenationSemantic proximity
TREM2 and the neuroimmunology of Alzheimer's disease.Semantic proximity
Shifting paradigms: The central role of microglia in Alzheimer's disease.Semantic proximity
The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progressionSemantic proximity
Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic diseaseSemantic proximity
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer's Disease.Semantic proximity
Select a neighboring publication to make it the new centre.