Article

DNMT1 inhibition reshapes subclone-associated transcriptional states and represents a therapeutic vulnerability in breast cancer

2026-05-04

Abstract excerpt

<title>Abstract</title> <p>Background: Intratumoral heterogeneity (ITH) drives therapeutic resistance, yet the relative contributions of genetic alterations and epigenetic regulation to transcriptional diversity remain unclear. In particular, the extent to which subclonal genetic variation constrains tumor cell states is still debated. <h4>Methods:</h4> We integrated single‑cell RNA sequencing from over one hund...

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Literature Corpus work: c624870e-0245-55dd-a018-17a004e179da
DOI: 10.21203/rs.3.rs-9236379/v1

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