Article

Clonal selection supported by single cell Dna sequencing reveals hormonal adaptation and resistance in locally advanced breast cancer During Neoadjuvant Aromatase Inhibition

2025-09-26

Abstract excerpt

<h4>Background</h4> The aromatase inhibitors (AI) letrozole and exemestane, are often used in sequence in targeting ER+ breast cancers. However resistance to AI poses a major barrier to sustained clinical benefit, while the biological mechanisms underlying the phenomenon remain largely unknown. In this study, we build on our clinical NeoLetExe trial, with the aim to investigate the molecular basis of resistance t...

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Literature Corpus work: 7b26bb7a-db79-55e2-a042-d43d4742a970
DOI: 10.1101/2025.09.24.678208

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Clonal selection supported by single cell Dna sequencing reveals hormonal adaptation and resistance in locally advanced breast cancer During Neoadjuvant Aromatase InhibitionDOI 10.1101/2025.09.24.678208Read

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