Intratumor Heterogeneity: Novel Approaches for Resolving Genomic Architecture and Clonal Evolution

Abstract excerpt

Abstract High-throughput genomic technologies have revealed a remarkably complex portrait of intratumor heterogeneity in cancer and have shown that tumors evolve through a reiterative process of genetic diversification and clonal selection. This discovery has challenged the classical paradigm of clonal dominance and brought attention to subclonal tumor cell populations that contribute to the cancer phenotype....

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