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Ultra-high-throughput IGH genotyping of 25 global populations reveals population-biased allelic diversity and homozygous V and D gene deletions.

Immunity - 14 Apr 2026

Corcoran Martin, Narang Sanjana, Kaduk Mateusz, Chernyshev Mark, Färnert Anna, Sundling Christopher, Karlsson Hedestam Gunilla B

Abstract excerpt

The extraordinary diversity of human immunoglobulin (IG) genes underpins effective antibody responses, yet the full scope and functional impact of germline-encoded IG variation across populations is largely unknown. Here, we present ImmuneDiscover, an ultra-high-throughput sequencing platform enabling individualized IG genotyping from nanogram-scale DNA and simultaneous analysis of over 1,000 individuals. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41844150
DOI: 10.1016/j.immuni.2026.01.026

Genes

IGH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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