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Article

Human IGH germline gene diversity and allele frequencies in 2486 individuals from 25 global populations delineated by ultra-high throughput genotyping

2025-08-07

Abstract excerpt

The extraordinary diversity of human immunoglobulin (IG) genes underpins effective antibody responses, yet the full scope and functional impact of germline-encoded IG variation across populations is largely unknown. Here, we present ImmuneDiscover, an ultra-high-throughput sequencing platform enabling individualized IG genotyping from nanogram-scale DNA and simultaneous analysis of over 1,000 individuals. Using Im...

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Literature Corpus work
0729d493-280c-5c12-8e1d-ecc6101fb13f
DOI
10.1101/2025.08.06.668935
Open publication

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Human IGH germline gene diversity and allele frequencies in 2486 individuals from 25 global populations delineated by ultra-high throughput genotypingDOI 10.1101/2025.08.06.668935
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