Article
Ultrasensitive allele inference from immune repertoire sequencing data with MiXCR.
Genome research - 23 Dec 2024
Mikelov Artem, Nefediev George, Tashkeev Alexander, Rodriguez Oscar L, Aguilar Ortmans Diego, Skatova Valeriia, Izraelson Mark, Davydov Alexey N, Poslavsky Stanislav, Rahmouni Souad, Watson Corey T, Chudakov Dmitriy, Boyd Scott D, Bolotin Dmitry
Abstract excerpt
Allelic variability in the adaptive immune receptor loci, which harbor the gene segments that encode B cell and T cell receptors (BCR/TCR), is of critical importance for immune responses to pathogens and vaccines. Adaptive immune receptor repertoire sequencing (AIRR-seq) has become widespread in immunology research making it the most readily available source of information about allelic diversity in...
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