Article

Reference-Free Germline Immunoglobulin Allele Discovery from B Cell Receptor Sequencing Data

2023-11-26

Abstract excerpt

Antibodies, or immunoglobulins, are a diverse set of molecules that play a critical role in adaptive immunity. They are generated in a process which begins with the recombination of germline V, D, and J gene segment alleles, and refined by hypermutation of these germline sequences upon antigen exposure. Antibody repertoire analysis often requires the knowledge of the germline V, D, and J alleles to detect hypermut...

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Literature Corpus work: 28d64c5b-8ed8-5a2b-9b19-28b73e1792de
DOI: 10.1101/2023.11.25.568681

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