Back to search

Article

Integrative Curation of Human and Rhesus Macaque Immunoglobulin Germline Loci for Population-Scale Immunogenomics 2267549

2026-07-28

Abstract excerpt

Abstract Introduction The immunoglobulin (IG) loci are among the most polymorphic and structurally complex regions of mammalian genomes, yet current germline references remain incomplete and inconsistent across species. We developed unified resources for human and rhesus macaque IG loci by integrating high-fidelity long-read genomic assemblies with matched AIRR-seq data. Our framework curates validated alleles, re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
25197259-a1fd-524e-8e8e-f9852177ef47
DOI
10.1093/jimmun/vkag141.1161
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Integrative Curation of Human and Rhesus Macaque Immunoglobulin Germline Loci for Population-Scale Immunogenomics 2267549DOI 10.1093/jimmun/vkag141.1161
Population-level genomic analysis of immunoglobulin loci variation in rhesus macaques reveals extensive germline diversity.Semantic proximity
A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus MacaquesSemantic proximity
An integrated human immunoglobulin germline resource linking allele diversity to expressed repertoire structureSemantic proximity
Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles.Semantic proximity
The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populationsSemantic proximity
The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations.Semantic proximity
AIRR-C Human IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genesSemantic proximity
Multiple full-length homozygous IGH haplotypes from Mauritian cynomolgus macaquesSemantic proximity
VDJ-Insights: simplifying the annotation of genomic IG and TCR regionsSemantic proximity
Novel Genes and Polymorphisms in Human Immunoglobulin Light Chains Across Diverse Populations Through Comprehensive IMGT AnalysisSemantic proximity
AIRR-C IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes.Semantic proximity
Uncovering diversity in the immunoglobulin heavy chain locus.Semantic proximity
Select a neighboring publication to make it the new centre.